Atherosclerotic Cardiovascular Disease

Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis
NCT05485961 | PHASE 2 | INTERVENTIONAL

This is a 2-part (phase 2b/3) prospective, interventional, multicenter, randomized, double-blind, placebo-controlled study. Part 1 (phase 2b) is a dose-finding study for CSL300 vs placebo. Part 2 (phase 3) aims to assess the efficacy of CSL300 on cardiovascular (CV) outcomes and safety in subjects with systemic inflammation and either atherosclerotic cardiovascular disease (ASCVD) or diabetes with end stage kidney disease (ESKD) undergoing maintenance dialysis.

Trial Information
226 Sites
2310 Participants
RECRUITING
18 Years

If interested, contact clinicaltrials@cslbehring.com or +1 610-878-4697 for more information

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SUBMIT
Nephrology Consultants, LLC
Huntsville,Alabama,United States,35805
DaVita Clinical Research Montgomery
Montgomery,Alabama,United States,36117
AKDHC Medical
Glendale,Arizona,United States,85305
Kidney Disease Medical Group
Glendale,Arizona,United States,91206
AKDHC Medical
Phoenix,Arizona,United States,85018
AKDHC Medical
Tucson,Arizona,United States,85705
National Institute of Clinical Research
Bakersfield,California,United States,93309
National Institute of Clinical Research
Bakersfield,California,United States,93309
Amicis Research Center
Beverly Hills,California,United States,90211
California Institute of Renal Research
Chula Vista,California,United States,91910
Davita Fullerton Dialysis Center
Fullerton,California,United States,92832
National Institute of Clinical Research, Inc.
Fullerton,California,United States,92835
St. Jude Medical Center
Garden Grove,California,United States,92843
National Institute of Clinical Research, Inc.
Garden Grove,California,United States,92843
National Institute of Clinical Research
Garden Grove,California,United States,92844
Sherman Medical Group, Inc
Glendale,California,United States,91204
Kidney Disease Medical Group
Glendale,California,United States,91206
Renal Consultants Medical Group
Granada Hills,California,United States,91344
California Institute of Renal Research
La Mesa,California,United States,91942
California Institute of Renal Research
La Mesa,California,United States,91942
Southern California Medical Research Center
La Palma,California,United States,90623
Southern California Medical Research Center
La Palma,California,United States,90623
Academic Medical Research Institute
Los Angeles,California,United States,90022
National Institute of Clinical Research, Inc.
Los Angeles,California,United States,90027
DaVita Carabello Dialysis Center
Los Angeles,California,United States,90033
Renal Medical AssociatesNARI
Lynwood,California,United States,90262
Amicis Research Center
Northridge,California,United States,91324
FORMAT Medical Research
Oxnard,California,United States,93036
Van Buren Dialysis Center
Riverside,California,United States,92504
National Nephrology Alliance Research Riverside
Riverside,California,United States,92505
California Institute of Renal Research
San Diego,California,United States,92111
California Institute of Renal Research
San Diego,California,United States,92123
North America Research Institute
San Dimas,California,United States,91773
North America Research Institute
San Dimas,California,United States,91773
Satellite Healthcare
San Jose,California,United States,95126
Nephrology Educational Services
Tarzana,California,United States,91356
Amicis Research Center
Vacaville,California,United States,95687
National Institute of Clinical Research, Inc
Victorville,California,United States,92392
DaVita Vista Del Sol Dialysis
Victorville,California,United States,92394
Kidney Associates of Colorado, P.C.
Denver,Colorado,United States,80210
Colorado Kidney Care
Denver,Colorado,United States,80230
Greater Hartford Nephrology, LLC
Bloomfield,Connecticut,United States,06002
Nephrology and Hypertension Associates PC
Middlebury,Connecticut,United States,06762
Nephrology Associates (Delaware)
Newark,Delaware,United States,19713
Boca Raton Regional Research Physicians Network Alliance
Boca Raton,Florida,United States,33431
Horizon Research Group LLC
Coral Gables,Florida,United States,33134
South Florida Nephrology Group, PA
Coral Springs,Florida,United States,33071
Family First Medical Research Center
Hialeah Gardens,Florida,United States,33016
Elixia Pines
Hollywood,Florida,United States,33024
South Florida Research Institute
Lauderdale Lakes,Florida,United States,33313
South Florida Research Organization LLC
Medley,Florida,United States,33166
Floridian Clinical Research
Miami Lakes,Florida,United States,33016
Total Research Group, LLC
Miami,Florida,United States,33126
Kidney and Hypertension Specialists of Miami
Miami,Florida,United States,33150
Nephrology Associates of South Miami
Miami,Florida,United States,33173
Elixia Central Florida
Orlando,Florida,United States,32806
Genesis Clinical Research
Tampa,Florida,United States,33603
Florida Kidney Specialists
Temple Terrace,Florida,United States,33637
Florida Premier Research Institute
Winter Park,Florida,United States,32789
Coastal Medical Research, LLC
Brunswick,Georgia,United States,31520
Renal Associates LLC
Columbus,Georgia,United States,31904
American Clinical Trials
Douglasville,Georgia,United States,30101
Atekha Nephrology Clinic LLC
Statesboro,Georgia,United States,30458
Nephrology Physician's LLC
Mishawaka,Indiana,United States,46545
Dunes Clinical Research LLC
Sioux City,Iowa,United States,57049
Kansas Nephrology Physicians, PA
Wichita,Kansas,United States,67214
Nephrology Associates of Kentuckiana, PSC
Louisville,Kentucky,United States,40205
Renal Associates of Baton Rouge
Baton Rouge,Louisiana,United States,70808
Paragon Health, Inc
Kalamazoo,Michigan,United States,49007
Michigan Kidney Consultants, PC
Pontiac,Michigan,United States,48341
St. Clair Nephrology Research
Roseville,Michigan,United States,48066
Center for Advanced Kidney Research, PLC
Saint Clair Shores,Michigan,United States,48081
DCR Edina
Minneapolis,Minnesota,United States,55404
DCR Edina
Minneapolis,Minnesota,United States,55404
Southwest Mississippi Nephrology PLLC
Brookhaven,Mississippi,United States,39601
Nephrology Associates, PC
Columbus,Mississippi,United States,39705
Nephrology and Hypertension Associates Ltd
Tupelo,Mississippi,United States,38801
Clinical Research Consultants
Kansas City,Missouri,United States,64111
GSR Enterprises, Inc.
Lincoln,Nebraska,United States,68510
Great Plains Health Nephrology
North Platte,Nebraska,United States,69101
DaVita Clinical Research Henderson
Henderson,Nevada,United States,89074
Kidney Specialists of Southern Nevada
Las Vegas,Nevada,United States,89106
Sierra Nevada Specialty Care
Reno,Nevada,United States,89511
Seacoast Kidney and Hypertension Specialists
Portsmouth,New Hampshire,United States,03801
Hypertension & Nephrology Association
Eatontown,New Jersey,United States,07724
New Jersey Kidney Care
Jersey City,New Jersey,United States,07305
DaVita Clinic Research Bronx
Bronx,New York,United States,10461
Albert Einstein College of Medicine Montefiore Medical Center
Bronx,New York,United States,10467
Mattoo & Bhat Medical Associates, P.C.
College Point,New York,United States,11356
Metrolina Nephrology Associates, PA
Charlotte,North Carolina,United States,28204
Durham Nephrology Associates, PA
Durham,North Carolina,United States,27704
East Carolina University
Greenville,North Carolina,United States,27858
North Carolina Nephrology, PA
Raleigh,North Carolina,United States,27610
HNC Dialysis, Ltd.
Columbus,Ohio,United States,43215
Northeast Clinical Research Center, LLC
Bethlehem,Pennsylvania,United States,18017
Columbia Nephrology
Columbia,South Carolina,United States,29203
DaVita Clinical Research
Spartanburg,South Carolina,United States,29306
Knoxville Kidney Center PLLC
Knoxville,Tennessee,United States,37923
Cussimanio Research Group LLC
Austin,Texas,United States,78751
Research Management, Inc.
Austin,Texas,United States,78758
US Renal Care
Dallas,Texas,United States,75237
Davita Clinical Research
El Paso,Texas,United States,79925
DaVita Clinical Research Horizon
El Paso,Texas,United States,79935
Fort Worth Renal Group
Fort Worth,Texas,United States,76110
DaVita Clinical Research
Houston,Texas,United States,77054
DaVita Clinical Research
Houston,Texas,United States,77054
Houston Medical Research Institute, LLC
Houston,Texas,United States,77074
Clinical Research Strategies, Inc.
Houston,Texas,United States,77090
Southwest Houston Research
Houston,Texas,United States,77099
Gamma Medical Research, Inc.
McAllen,Texas,United States,78503
National Institute of Clinical Research, Inc.
San Antonio,Texas,United States,78204
DaVita Clinical Research
San Antonio,Texas,United States,78229
Davita Clinical Research
San Antonio,Texas,United States,78251
DCRSan Antonio Stone Oak
San Antonio,Texas,United States,78258
DaVita Clinical Research North Houston
Shenandoah,Texas,United States,77384
DCRNorfolk Great Bridge
Chesapeake,Virginia,United States,23320
Nephrology Associates of Northern Virginia Inc
Fairfax,Virginia,United States,22033
Peninsula Kidney Associates
Hampton,Virginia,United States,23666
Tidewater Kidney Specialists
Norfolk,Virginia,United States,23502
Nephrology and Hypertension Associates
Bluefield,West Virginia,United States,24701
Royal North Shore Hospital (RNSH)
Saint Leonards,New South Wales,Australia,2065
Concord Repatriation General Hospital
Sydney,New South Wales,Australia,2139
Cairns Hospital
Cairns,Queensland,Australia,4870
Sunshine Coast University Private Hospital
Nambour,Queensland,Australia,4560
Princess Alexandra Hospital
Woolloongabba,Queensland,Australia,4102
Monash Medical Centre
Clayton,Victoria,Australia,3168
Sunshine Hospital
St Albans,Victoria,Australia,3021
Sunshine Hospital
St Albans,Victoria,Australia,3021
Fiona Stanley Hospital
Murdoch,Victoria,Australia,6150
Wollongong Renal Unit
Wollongong,Victoria,Australia,2500
OnzeLieveVrouwziekenhuis VZW
Aalst,Victoria,Belgium,9300
OnzeLieveVrouwziekenhuis VZW
Aalst,Victoria,Belgium,9300
Imelda Ziekenhuis
Bonheiden,Victoria,Belgium,2820
AZ SintLucas
Gent,Victoria,Belgium,9000
Universitair Ziekenhuis Leuven
Leuven,Victoria,Belgium,3000
CHR de la Citadelle
Liège,Victoria,Belgium,4000
CHR de la Citadelle
Liège,Victoria,Belgium,4000
Dialysis Center VIA DIAL OOD
Stara Zagora,Victoria,Bulgaria,6000
University of Alberta Hospital
Edmonton,Alberta,Canada,T6G2P4
Queen Elizabeth II Health Sciences Centre
Halifax,Nova Scotia,Canada,B3H3A6
St. Josephs Healthcare Hamilton
Hamilton,Ontario,Canada,L8N4A6
Kingston Health Sciences Centre
Kingston,Ontario,Canada,K7L2V7
London Health Sciences Centre University Hospital
London,Ontario,Canada,N6A5A5
Lakeridge Health Oshawa
Oshawa,Ontario,Canada,L1G2B9
McGill University Health Centre
Montreal,Quebec,Canada,H4A3J1
Aalborg Universitetshospital
Aalborg,Quebec,Denmark,9000
Herlev Hospital
Herlev,Quebec,Denmark,2730
Trail Nation Nordsjllands Hospital
Hillerød,Quebec,Denmark,3400
CHU Amiens Nephrology Dialysi Transplantation Department
Amiens,Quebec,France,80054
CHU de Caen
Caen,Quebec,France,14000
AURA Paris Plaisance
Paris,Quebec,France,75014
CHU Rangueil
Toulouse,Quebec,France,31059
ChariteUniversitatsmedizin Berlin
Berlin,Quebec,Germany,13353
Nierenzentrum Bad Knig
Hessen,Quebec,Germany,64732
Westpfalz Klinikum GmbH
Kaiserslautern,Quebec,Germany,67655
UKSH Universitatsklinik SchleswigHolstein
Kiel,Quebec,Germany,24105
Universittsmedizin der Johannes GutenbergUniversitt Mainz
Mainz,Quebec,Germany,55131
Nephrologisches Zentrum VillingenSchwenningen
Villingen-Schwenningen,Quebec,Germany,78052
Nephrologisches Zentrum VillingenSchwenningen
Villingen-Schwenningen,Quebec,Germany,78052
University General Hospital of Ioannina
Ioánnina,Quebec,Greece,45110
General Hospital of Ioannina G. Hatzikosta
Ioánnina,Quebec,Greece,45445
Nephrological Clinic University Hospital, University of Thessaly
Larissa,Quebec,Greece,41110
University Hospital of Patras
Rio,Quebec,Greece,26504
Aristotle University, Hippokration
Thessaloniki,Quebec,Greece,54642
General Hospital of Thessaloniki, Agios Pavlos
Thessaloníki,Quebec,Greece,55134
Papageorgiou General Hospital of Thessaloniki
Thessaloníki,Quebec,Greece,56403
Nephrology Department G. Papanikolaou General Hospital
Thessaloníki,Quebec,Greece,57010
General Hospital of Arta
Árta,Quebec,Greece,47100
B. Braun Avitum . Dialziskzpont Kistarcs
Kistarcsa,Quebec,Hungary,2143
Carmel Medical Center
Haifa,Quebec,Israel,3436212
Edith Wolfson Medical Center
H̱olon,Quebec,Israel,58100
Rabin Medical Center
Petah Tikva,Quebec,Israel,4941492
Chaim Sheba Medical Center (Sheba TelHashomer Medical Center )
Ramat Gan,Quebec,Israel,3109601
Ichilov HospitalTelAviv Sourasky Medical Center
Tel Aviv,Quebec,Israel,84100
Ziv Medical Center
Zefat,Quebec,Israel,13110
ASST degli Spedali Civili di Brescia
Brescia,Quebec,Italy,25123
Azienda Ospedaliera Sant'Anna e San Sebastiano di Caserta
Caserta,Quebec,Italy,81100
Ospedale Santa Maria Annunziata
Florence,Quebec,Italy,50012
A. O. Universitaria Ospedali Riuniti di Foggia Farmacia Osp
Foggia,Quebec,Italy,71122
Universit degli Studi di Messina
Messina,Quebec,Italy,98124
ICS Maugeri S.p.A. SB Universit di Pavia Fondazione Salvatore Maugeri IRCCS
Pavia,Quebec,Italy,2700
University of Verona
Peschiera Del Garda,Quebec,Italy,37019
Ospedale Santo Stefan
Prato,Quebec,Italy,59100
Rimini Hospital
Rimini,Quebec,Italy,47923
Ospedale Casa Sollievo della Sofferenza (CSS)
San Giovanni Rotondo,Quebec,Italy,71013
Azienda Ospedaliera Universitaria Integrata Verona Ospedale Borgo Trento
Verona,Quebec,Italy,37126
Daiyukai Daiichi Hospital
Ichinomiya-shi,Aichi,Japan,491-8551
Juntendo University Urayasu Hospital
Urayasu-shi,Chiba-ken,Japan,279-0021
Steel Memorial Yawata Hospital
Kitakyushu-shi,Fukuoka,Japan,805-0050
Maebashi Hirosegawa Clinic
Maebashi-shi,Gunma,Japan,371-0022
Joumou Ohashi Clinic
Maebashi-shi,Gunma,Japan,371-0046
Teine Urological Clinic
Sapporo-shi,Hokkaido,Japan,006-0816
Omi freai Hospital
Kusatsu-shi,Shiga,Japan,525-8585
Tokyo Womens Med University
Shinjuku-Ku,Tokyo,Japan,162-8666
Matsunami General Hospital
Hashima-gun,Tokyo,Japan,501-6062
Ishikiriseiki Hospital
Higashiosaka-shi,Tokyo,Japan,579-8026
Miki Internal Medicine Urology Clinic
Hokkaido,Tokyo,Japan,041-1121
Tokyo Medical University Ibaraki Medical Center
Inashiki-gun,Tokyo,Japan,300-0332
Ueyama Hospital
Kagoshima-shi,Tokyo,Japan,890-0073
St. Mary's Hospital
Kurume-shi,Tokyo,Japan,830-8543
Kurume University Hospital
Kurume,Tokyo,Japan,830-0011
Rakuwakai Otowa Kinen Hospital
Kyoto-Shi,Tokyo,Japan,607-8116
Nagaoka RedCross Hospital
Nagaoka-Shi,Tokyo,Japan,940-2085
Daido Hospital
Nagoya-shi,Tokyo,Japan,457-8511
Chubu Rosai Hospital
Nagoya,Tokyo,Japan,455-8530
Omihachiman Community Medical Center Kidney Center
Omihachiman,Tokyo,Japan,523-0082
Oguranaika Jin Cinic
Oyama-shi,Tokyo,Japan,323-0831
Ibaraki Seinan Medical Center Hospital
Sakaimachi,Tokyo,Japan,306-0433
Kurosawa Hospital
Takasaki-Shi,Tokyo,Japan,370-1203
Kikuchi Medical Clinic
Tsukuba-shi,Tokyo,Japan,305-0861
St.Hill Hospital
Ube-shi,Tokyo,Japan,755-0155
Bosei Kannai Clinic
Yokohama-shi,Tokyo,Japan,231-0048
Sanin Rosai Hospital
Yonago-shi,Tokyo,Japan,683-8605
SMG SNU Boramae Medical Center
Ilsan-gu,Seoul,Korea, Republic of,7061
National Health Insurance Service Ilsan Hospital
Goyang-si,Seoul,Korea, Republic of,10444
Konkuk University Medical Center
Gwangju,Seoul,Korea, Republic of,5030
Seoul National University Hospital
Seoul,Seoul,Korea, Republic of,03080
Unidade Local de Sade de Braga, E. P. E.
Braga,Seoul,Portugal,4710-243
Unidade Local de Sade de So Jos, E. P. E.
Oeiras,Seoul,Portugal,2790
Fundeni Clinical Institute
Bucuresti,Seoul,Romania,22328
Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta (Emergency Clinic Hospital Constanta)
Constanta,Seoul,Romania,900591
Spital Judetean de Urgenta Satu Mare
Satu Mare,Seoul,Romania,440055
Uppsala Universitet Akademiska Sjukhuset
Uppsala,Seoul,Sweden,75185
Bradford Teaching Hospitals NHS Foundation Trust
Bradford,Seoul,United Kingdom,BD96RJ
Altnagelvin Area Hospital
Londonderry,Seoul,United Kingdom,BT476SB
Royal Stoke University Hospital
Stoke-on-Trent,Seoul,United Kingdom,ST46QG

Study Eligibility Criteria

Additional Studies

Additional studies can be found at ClinicalTrials.gov