- 1. Adult aged ≥18 years at enrolment.
- 2. Patient diagnosed with chronic HF ≥3 months prior to signature of informed consent.
- 3. Patient has at least 1 record of LVEF documented in patient medical record in the 24 months prior to signature of informed consent. NOTE: If the proportion of patients with HFpEF exceeds 20% of the target sample size, enrolment of patients with an LVEF ≥50% may be capped.
- 4. Patient treated with ACEi/ARB/ARNi at enrolment.
- 5. Patient treated with or a candidate for treatment with MRA per a relevant treatment guideline (e.g., HF, CKD, resistant hypertension) at enrolment.
- 6. Patient at increased risk of hyperkalaemia due to one or more of the following:
- 1. Current hyperkalaemia (sK+ \>5.0 mEq/l) at enrolment
- 2. Record of documented hyperkalaemia (sK+ \>5.0 mEq/l) in the 24 months prior to signature of informed consent
- 3. eGFR \<45 ml/min/1.73 m2, or CKD Stage ≥3b.
- 7. Patient judged by the Investigator to have sufficient cognitive ability to participate.
- 8. Signed informed consent provided
Heart Failure
Cardiovascular and Renal Treatment in Heart Failure Patients With Hyperkalaemia or at High Risk of Hyperkalaemia
NCT04864795 | OBSERVATIONAL
The CARE-HK in HF is a registry study based on the hypothesis that adherence to guidelines is associated with improved real-world outcomes for heart failure (HF) patients. For the purpose of this study, adherence to guidelines is defined as adherence to RAASi treatment recommendations, according to the AHA/ACC and ESC guidelines. Objectives relating to patiromer effectiveness will only be evaluated if a sufficient number of patients are available. The study aims to evaluate in patients at high risk of hyperkalaemia; patients treated with ACEi/ARB/ARNi, and either treated with or candidates for treatment with MRA.
Trial Information
If interested, contact clinicaltrials@cslbehring.com or +1 610-878-4697 for more information
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University of Arkansas for Medical Sciences
Little Rock,Arkansas,United States,72205
UC San Diego Sulpizio Cardiovascular Center
La Jolla,California,United States,92037
Amicis Research Center
Northridge,California,United States,91324
Bridgeport Hospital
Bridgeport,Connecticut,United States,06610
Bethesda Hospital East
Boynton Beach,Florida,United States,33425
Clearwater Cardiovascular Consultants
Clearwater,Florida,United States,33756
Innovative Research of West Florida, Inc.
Clearwater,Florida,United States,33756
Inpatient Research Clinic, LLC
Hialeah,Florida,United States,33013
Clearwater Cardiovascular Consultants
Largo,Florida,United States,33777
D&H National Research Centers
Miami,Florida,United States,33173
Southwest Florida Research, LLC
Naples,Florida,United States,34102
Peace River Cardiovascular Center
Port Charlotte,Florida,United States,33952
Clearwater Cardiovascular and Interventional Consultants
Safety Harbor,Florida,United States,32695
Florida Cardiology P.A
Winter Park,Florida,United States,32792
IACT Health
Columbus,Georgia,United States,31904
Cardiology Care Clinics
Eatonton,Georgia,United States,31024
NSC Research
Johns Creek,Georgia,United States,30024
Chicago Medical Research, LLC
Hazel Crest,Illinois,United States,60429
Prairie Cardiovascular Consultants, Ltd.
Springfield,Illinois,United States,62701
Cardiovascular Medicine, P.C.
Davenport,Iowa,United States,52803
Central Cardiology Associates
Elizabethtown,Kentucky,United States,42701
Maine Health
Biddeford,Maine,United States,04005
Johns Hopkins University
Baltimore,Maryland,United States,21218
TidalHealth Peninsula Regional Inc.
Salisbury,Maryland,United States,21801
Ascension St. Mary's Hospital
Saginaw,Michigan,United States,48601
Minneapolis Heart Institute Foundation
Minneapolis,Minnesota,United States,55407
St. Louis Heart and Vascular
Bridgeton,Missouri,United States,63044
Saint Luke's Hospital of Kansas City
Kansas City,Missouri,United States,64111
St. Louis University
Saint Louis,Missouri,United States,63104
Logan Health Research
Kalispell,Montana,United States,59901
Virtua Medical Group PA
Marlton,New Jersey,United States,08053
Raritan Bay Primary and Cardiology Associates
Matawan,New Jersey,United States,07747
The Heart House
Sewell,New Jersey,United States,08080
Albany Stratton VA Medical Center
Albany,New York,United States,12208
Capital Cardiology Associates
Albany,New York,United States,12211
South Shore University Hospital
Bay Shore,New York,United States,11706
Focus Clinical Research Solutions
Charlotte,North Carolina,United States,28204
Nephrology Associates of Greater Cincinnati
Cincinnati,Ohio,United States,45236
Rama Research LLC
Marion,Ohio,United States,43302
The Heart and Medical Center
Durant,Oklahoma,United States,74701
Capital Area Research, LLC
Camp Hill,Pennsylvania,United States,17011
UPMC Presbyterian Hospital
Pittsburgh,Pennsylvania,United States,15213
UT Southwestern Medical Center
Dallas,Texas,United States,75390
East Texas Cardiology PA
Houston,Texas,United States,77002
Biopharma Informatic, LLC
Houston,Texas,United States,77084
Texas Cardiology Associates of Houston
Kingwood,Texas,United States,77339
Complete Heart Care
McKinney,Texas,United States,75071
Baylor Scott & White Round Rock
Round Rock,Texas,United States,78665
Baylor Scott & White Health Temple
Temple,Texas,United States,76508
Victoria Heart & Vascular Center
Victoria,Texas,United States,77901
Richmond Cardiology Associates
Mechanicsville,Virginia,United States,23116
William S. Middleton Memorial VA Hospital
Madison,Wisconsin,United States,53705
KH St. Josef Braunau
Braunau Am Inn,Wisconsin,Austria,53705
LKH Universitatklinikum Graz
Graz,Wisconsin,Austria,53705
Ordensklinkum Linz Elisabethinen
Linz,Wisconsin,Austria,53705
Allgemeines Krankenhaus der Stadt Wien
Wien,Wisconsin,Austria,53705
Imed privat
Wien,Wisconsin,Austria,53705
Klinik Floridsdorf
Wien,Wisconsin,Austria,53705
Cliniques Universitaires de Bruxelles Hopital Erasme
Brussels,Wisconsin,Belgium,53705
Cliniques Universitaires SaintLuc
Bruxelles,Wisconsin,Belgium,53705
Grand Hpital de Charleroi
Charleroi,Wisconsin,Belgium,53705
AZ SintBlasius
Dendermonde,Wisconsin,Belgium,53705
CHU de Lige
Liège,Wisconsin,Belgium,53705
AZ Glorieux
Ronse,Wisconsin,Belgium,53705
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS
Bologna,Wisconsin,Italy,53705
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
Brescia,Wisconsin,Italy,53705
Azienda Ospedaliera Universitaria Arcispedale Sant'Anna
Ferrara,Wisconsin,Italy,53705
Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia
Foggia,Wisconsin,Italy,53705
A.O.U. Policlinico di Modena
Modena,Wisconsin,Italy,53705
Centro Cardiologico MonzinoIRCCS
Monza,Wisconsin,Italy,53705
Azienda Ospedaliera Universitaria "Federico II"
Napoli,Wisconsin,Italy,53705
Azienda Ospedaliero Universitaria Pisana
Pisa,Wisconsin,Italy,53705
Arcispedale S. Maria Nuova Azienda Ospedaliera di Reggio Emilia
Reggio Emilia,Wisconsin,Italy,53705
IRCCS San Raffaele Pisana
Roma,Wisconsin,Italy,53705
IRCCS Ospedale Policlinico San Martino
San Martino,Wisconsin,Italy,53705
Azienda Servizi Sanitari Triestina
Triest,Wisconsin,Italy,53705
Hospital Universitario Central de Asturias
Oviedo,Asturias,Spain,33011
Hospital Universitario Severo Ochoa
Leganés,Madrid,Spain,33011
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda,Madrid,Spain,33011
Complejo Hospitalario de Navarra
Pamplona,Navarra,Spain,33011
Hospital Universitari Germans Trias i Pujol
Badalona,Navarra,Spain,33011
Hospital clinic de Barcelona
Barcelona,Navarra,Spain,33011
Hospital de la Santa Creu i Sant Pau
Barcelona,Navarra,Spain,33011
Hospital Universitari de Bellvitge
Barcelona,Navarra,Spain,33011
Hospital Universitari Vall d'Hebron
Barcelona,Navarra,Spain,33011
Hospital Universitario Virgen de las Nieves
Granada,Navarra,Spain,33011
Juan Ramon Jimenez Hospital
Huelva,Navarra,Spain,33011
Complejo Hospitalario de Jaen
Jaén,Navarra,Spain,33011
Complejo Hospitalario Universitario A Corua
La Coruña,Navarra,Spain,33011
Hospital Universitario de Gran Canaria Dr. Negrin
Las Palmas De Gran Canaria,Navarra,Spain,33011
Hospital Universitario Clinico San Carlos
Madrid,Navarra,Spain,33011
Hospital Universitario Infanta Leonor
Madrid,Navarra,Spain,33011
Hospital Universitario La Paz
Madrid,Navarra,Spain,33011
Hospital Universitario Ramon y Cajal
Madrid,Navarra,Spain,33011
Hospital Clinico Universitario Virgen de la Victoria
Málaga,Navarra,Spain,33011
Hospital Universitario Puerto Real
Puerto Real,Navarra,Spain,33011
Hospital Universitario Virgen del Roco
Sevilla,Navarra,Spain,33011
Hospital Universitario Virgen Macarena
Sevilla,Navarra,Spain,33011
Hosp. Universitari Sant Joan de Reus
Tarragona,Navarra,Spain,33011
Kantonsspital Aarau AG
Aarau,Navarra,Switzerland,33011
University Hospital Basel
Basel,Navarra,Switzerland,33011
Hpitaux Universitaires de Genve HUG
Geneva,Navarra,Switzerland,33011
Centre Hospitalier Universitaire Vaudois
Lausanne,Navarra,Switzerland,33011
Luzerner Kantonsspital
Luzern,Navarra,Switzerland,33011
Kantonsspital St. Gallen
Saint Gallen,Navarra,Switzerland,33011
Buckinghamshire Healthcare NHS Trust
Amersham,Navarra,United Kingdom,33011
Bradford Royal Infirmary
Bradford,Navarra,United Kingdom,33011
Royal Devon and Exeter Hospital (Wonford)
Exeter,Navarra,United Kingdom,33011
Northwick Park Hospital
Harrow,Navarra,United Kingdom,33011
Royal Liverpool University Hospital
Liverpool,Navarra,United Kingdom,33011
Barts Health NHS Trust
London,Navarra,United Kingdom,33011
King's College Hospital
London,Navarra,United Kingdom,33011
William Harvey Clinical Research Centre
London,Navarra,United Kingdom,33011
Royal Victoria Infirmary
Newcastle,Navarra,United Kingdom,NE14LP
Derriford Hospital
Plymouth,Navarra,United Kingdom,NE14LP
Whiston Hospital
Rainhill,Navarra,United Kingdom,NE14LP
Study Eligibility Criteria
Additional Studies
Additional studies can be found at ClinicalTrials.gov