- * Males and females aged ≥ 12 years
- * Diagnosed with clinically confirmed C1-INH HAE
- * Experienced ≥ 3 HAE attacks during the 3 months before Screening
- * Participated in the Run-in Period for at least 1 month (CSL312-naïve subjects only)
- * Experienced at least an average of 1 HAE attack per month during the Run-in Period
Hereditary Angioedema
Long-term Safety and Efficacy of CSL312 (Garadacimab) in the Prophylactic Treatment of Hereditary Angioedema Attacks
NCT04739059 | PHASE 3 | INTERVENTIONAL
This phase 3b study will evaluate long-term safety and efficacy of CSL312 (also known as garadacimab) when administered subcutaneously (SC)
Trial Information
If interested, contact clinicaltrials@cslbehring.com for more information
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Clinical Research Center of Alabama
Birmingham,Alabama,United States,35209
Research Solutions of Arizona
Litchfield Park,Arizona,United States,85340
Medical Research of Arizona
Scottsdale,Arizona,United States,85251
Little Rock Allergy & Asthma Clinic
Little Rock,Arkansas,United States,72205
Donald S. Levy M.D.
Orange,California,United States,92868
Raffi Tachdjian MD, Inc.
Santa Monica,California,United States,90404
Allergy & Asthma Clinical Research
Walnut Creek,California,United States,94598
Institute for Asthma and Allergy PC
Chevy Chase,Maryland,United States,20815
Bernstein Clinical Research Center, LLC
Cincinnati,Ohio,United States,45236
PennState Health Milton S. Hershey Medical Center
Hershey,Pennsylvania,United States,17033
AARA Research Center
Dallas,Texas,United States,75231
Campbelltown Hospital Western Sydney University
Campbelltown,New South Wales,Australia,2560
The Alfred Hospital
Melbourne,Victoria,Australia,3004
Fiona Stanley Hospital, Department of Clinical Immunology
Murdoch,West Australia,Australia,6150
University of Alberta Research Transition Facility
Edmonton,Alberta,Canada,T6G2B7
McMaster University
Hamilton,Ontario,Canada,L8N3Z5
Ottawa Allergy Research Corp
Ottawa,Ontario,Canada,K1H1E4
Gordon Sussman Clinical Research
Toronto,Ontario,Canada,M3B3S6
Montreal Clinical Research Institute
Montréal,Quebec,Canada,H2W1R7
University hospital St. Anna Ustav klinicke imunologie a alergologie, Fakultn nemocnice u sv. Anny v Brn
Brno,Czechia,65691
University Hospital Motol
Praha 5,Czechia,15006
Charit Universittsmedizin Berlin
Berlin,Germany,10117
Universittsklinikum Frankfurt
Frankfurt,Germany,60590
Johannes GutenbergUniversitt KR, Hautklinik und Poliklinik der Universittsmedizin, Clinical Research Center
Mainz,Germany,55131
HZRM Haemophilie Zentrum Rhein Main GmbH
Mörfelden-Walldorf,Germany,64546
The University of Hong Kong, Queen Mary Hospital
Hong Kong,Hong Kong
Semmelweis Egyetem Altalanos Orvostudomnyi Kar Belgygyszati s Hematolgiai Klinika
Budapest,Hungary,1088
Barzilai University Medical Center
Ashkelon,Israel,7830604
Koga Community Hospital
Shizuoka,Daikakuji Yaizu-shi,Japan,425-0088
Mie University Hospital
Mie,Edobashi, Tsu-shi,Japan,Edobashi,Tsu-shi
Juntendo University Hospital
Tokyo,Hongo Bunkyo-ku,Japan,113-8431
Saitama Medical Center
Saitama,Kamoda Kawagoe-shi,Japan,350-8550
St. Marianna University School of Medicine Hospital
Kanagawa,Kawasaki-shi,Japan,216-8511
Clover Hospital
Kanagawa,Kugenumaishigami, Fujisawa-shi,Japan,251-0025
Saiyu Soka Hospital
Saitama,Matsubara Soka-shi,Japan,340-0041
National Hospital Organization Disaster Medical Center
Tokyo,Midoricho, Tachikawa-shi,Japan,190-0014
Saga University Hospital
Saga,Nebeshima, Saga-shi,Japan,849-8501
Local Incorporated Administrative Agency Osaka City Hospital Organization Osaka City General Hospital
Miyakojima-ku,Osaka-shi,Japan,534-0021
Amsterdam UMC, location AMC
Amsterdam,Netherlands,1105
Auckland City Hospital
Grafton,Auckland,New Zealand,1023
NRC Institute of Immunology FMBA Russia
Moscow,Russian Federation,115522
Hospital Universitari General de La Vall d'Hebron
Barcelona,Spain,8035
Hospital Gregorio Maran, Servicio de Alergia
Madrid,Spain,28007
Taichung Veterans General Hospital
Taichung City,Taiwan,407
Study Eligibility Criteria
Additional Studies
Additional studies can be found at ClinicalTrials.gov