- * Diagnosis of active Rheumatoid Arthritis (RA) by standard criteria (American Rheumatism association (ARA) \[1987\] or American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) \[2010\]) at least 16 weeks prior to screening
- * ACR global functional status class of 1 to 3
- * Documented evidence of inadequate response tumor necrosis factor (TNF) inhibitors
- * All subjects must have been receiving treatment with a minimum dose of 15 mg per week of Methotrexate for at least 12 weeks and at a stable dose for 28 days prior to screening. A dose as low as 10 mg Methotrexate is permitted if 15 mg could not be reached, due to toxicity. In Japan, Korea and Taiwan, a minimum dose of 7.5 mg per week is permitted. Additional treatment with Hydroxychloroquine or Chloroquine is permitted, if it is at a dose approved for the treatment of RA and the dose has been stable for at least 28 days prior to screening
- * Minimum of 6 swollen and 6 tender joints on a 66/68 joint count at screening and at baseline (Day 1)
- * Elevated High-sensitivity (hs) CRP and/or ESR
Rheumatoid Arthritis
Phase IIB Dose Ranging Study in Subjects With Moderate to Severe Rheumatoid Arthritis
NCT02015520 | PHASE 2 | INTERVENTIONAL
The primary purpose of this study is to identify an appropriate dose of study medication.
Trial Information
If interested, contact clinicaltrials@cslbehring.com for more information
CSL Behring respects your privacy. For an explanation of how CSL Behring will use the information you are submitting, please view our Privacy Policy
Rheumatology Associates Of North Alabama, P.C.
Huntsville,Alabama,United States,35801
Mercy Clinic Hot Springs Communities
Hot Springs,Arkansas,United States,71913
Valerius Med Group & Res Ctr Of Greater Long Beach, Inc.
Long Beach,California,United States,90806
Desert Medical Advances
Palm Desert,California,United States,92260
Sarasota Arthritis Research Center
Sarasota,Florida,United States,34239
Clinical Pharmacology Study Group
Worcester,Massachusetts,United States,01605
St. Paul Rheumatology, P.A.
Eagan,Minnesota,United States,55121
Physician Research Collaboration, Llc
Lincoln,Nebraska,United States,68516
Albuquerque Center For Rheumatology
Albuquerque,New Mexico,United States,87102
Albuquerque Clinical Trials
Albuquerque,New Mexico,United States,87102
Joint And Muscle Medical Care And Research Institute (Jmmcri)
Charlotte,North Carolina,United States,28204
Physicians East, Pa
Greenville,North Carolina,United States,27834
Cincinnati Rheumatic Disease Study Group
Cincinnati,Ohio,United States,45219
Paramount Medical Research & Consulting, Llc
Middleburg Heights,Ohio,United States,44130
Arthritis & Rheumatology Center Of Oklahoma Pllc
Oklahoma City,Oklahoma,United States,73103
Health Research Of Oklahoma
Oklahoma City,Oklahoma,United States,73103
Healthcare Research Consultants
Tulsa,Oklahoma,United States,74135
Low Country Rheumatology
Charleston,South Carolina,United States,29406
Rheumatology Consultants Pllc
Knoxville,Tennessee,United States,37909
Center For Inflammatory Disease
Nashville,Tennessee,United States,37203
Seattle Rheumatology Associates
Seattle,Washington,United States,98122
Local Institution
Quilmes,Buenos Aires,Argentina,1878
Local Institution
Buenos Aires,Argentina,1121
Local Institution
Buenos Aires,Argentina,1426
Local Institution
Cordoba,Argentina,5000
Local Institution
Tucuman,Argentina,4000
Cividino Medicine Professional Corporation
Hamilton,Ontario,Canada,L8N2B6
Credit Valley Rheumatology
Mississauga,Ontario,Canada,L5M2V8
Dr. Latha Naik Medical Professional Corporation
Saskatoon,Saskatchewan,Canada,S7K3H3
Local Institution
Bordeaux Cedex,France,33076
Local Institution
Paris Cedex 14,France,75679
Local Institution
Poitiers,France,86021
Local Institution
Budapest,Hungary,1023
Local Institution
Debrecen,Hungary,4012
Local Institution
Veszprem,Hungary,8200
Local Institution
Catanzaro,Italy,88100
Local Institution
Firenze,Italy,50139
Local Institution
Napoli,Italy,80131
Local Institution
Pisa,Italy,56126
Local Institution
Chiba-shi,Chiba,Japan,2608712
Local Institution
Kitakyushu-shi,Fukuoka,Japan,8078555
Local Institution
Kato-shi,Hyogo,Japan,6731462
Local Institution
Nagano-shi,Nagano,Japan,3808582
Local Institution
Sasebo-shi,Nagasaki,Japan,8571195
Local Institution
Shinjuku-Ku,Tokyo,Japan,1608582
Local Institution
Toshima-ku,Tokyo,Japan,1708476
Local Institution
Nishimura,Wakayama,Japan,6492211
Local Institution
Tijuana,Baja California,Mexico,22010
Local Institution
Leon,Guanajuato,Mexico,37000
Local Institution
Merida,Yucatan,Mexico,97000
Local Institution
Merida,Yucatan,Mexico,97070
Local Institution
Guadalajara,Mexico
Local Institution
San Luis Potosi,Mexico,78200
Local Institution
Cape Town,Western CAPE,South Africa,7500
Local Institution
Stellenbosch,Western Cape,South Africa,7600
Study Eligibility Criteria
Additional Studies
Additional studies can be found at ClinicalTrials.gov