Multifocal Motor Neuropathy (MMN)

A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN)

NCT00701662 | PHASE 2 | INTERVENTIONAL

The objective of this study is to assess efficacy, safety, and convenience of purified human antibodies administered under the skin in the treatment of MMN patients.

3 Sites

8 Participants

Recruiting

18 Years to 2 Years

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SUBMIT

San Raffaele Hospital

Milan,Italy

Inselspital

Bern,Switzerland

Dept. Clinical Immunology, Oxford Radcliffe Hospitals

Oxford,United Kingdom

Study Eligibility Criteria

Inclusion Criteria

* Patients with documented clinical diagnosis and electrophysiological evidence of MMN
* Patients who have previously responded to intravenous immunoglobulin (IVIG) and have been on stable treatment with IVIG for at least 12 weeks prior to screening
* Patients treated with the equivalent of ≥0.4g/kg body weight (bw) IVIG per month
* Provision of informed consent by patient

Exclusion Criteria

* Aspartate aminotransferase (ASAT) or alanine aminotransferase (ALAT) concentration \>2.5 times the upper normal limit (UNL)
* Creatinine concentration \>1.5 times the UNL
* Known allergic reactions to blood products
* Any skin disease interfering with the assessment of injection site reactions
* Any other medical condition, which in the opinion of the investigator, might interfere with successful completion of the protocol
* Any condition likely to interfere with the evaluation of the study drug or satisfactory conduct of the trial
* Participation in a study with an investigational drug within three months prior to enrolment
* Patients treated with the equivalent of \>2.0g/kg bw IVIG per month

Additional Studies

Additional studies can be found at ClinicalTrials.gov